Furthermore, the upregulation of Ccl5 in the kidneys of Ly6Clo monocyte-like cells was in accordance with the suggested involvement of the CCL5/CCR5 axis in the recruitment of Ly6Clo monocytes in the CNS of another SLE model in FcγRIIB-/-Yaa mice (25). This evidence concerns the gene CCL5 and systemic lupus erythematosus.