Figures 2F, G shows the independent correlation factors for TR of MCD. Serum IgE ≥ 523.5 IU/mL (HR = 0.604, 95% CI = 0.413–0.884; P =0.009), and GC-dose (HR = 0.621, 95% CI = 0.528–0.731; P < 0.001) were independent TR correlation factors. As shown in Figure 2H, after adjusting for age, AKI, GC-dose, and UA levels in the multivariate Cox regression model, the cumulative TR rate of MCD patients in the high-IgE group was significantly lower than that in the low-IgE group (P = 0.009). This evidence concerns the gene IGHE and acute kidney injury.