IGHE and acute kidney injury: Figure 4 shows that the UA levels in the high-IgE group were significantly higher than that in the low-IgE group at month 1, 2, 3, and 6 of follow-up (P < 0.05), and there were no significant differences between serum albumin, eGFR, and UP/Cr of the MCD patients in the two groups at month 0, 1, 2, 3, 6, and 12 of follow-up (P > 0.05). Although 26.9% of the patients experienced AKI at the onset (as shown in Table 2), their renal functions gradually recovered as the proteinuria disappeared.