Nevertheless, although we confirmed that the patient serum did not contain anti-Dsc3, anti-SPCA1, or anti-CHRM3 Abs (which have been reported to be involved in the pathogenicity of pemphigus serum (25, 26)), we cannot completely exclude that the adjustment of the anti-DSG3 IgG4 titers could have induced an increased concentration of other pathogenic non-DSG Abs. This evidence concerns the gene DSC3 and pemphigus.