CD4 and cranioectodermal dysplasia: Although the interleukin signaling is a major feature of active CD4+ T cells in CeD pathophysiology (53), the number of differentially expressed interleukins that we detected was low, but this could be due to the limit of detection of scRNAseq for interleukin genes or by the fact that the CD4+ T cells that contribute to CeD reside predominantly in the small intestine, while very little of them are in circulation.