For CD4+ T cells, the genes upregulated after the seroconversion for CeD (Figures 4A, B) were significantly enriched for pathways related to immune-related functions (P adjusted value < 0.05) such as “TCR signaling” and “Generation of second messenger molecules” and mainly included genes such as CD3G, CD3E and CD3D (Figure 4A and Supplementary Table 4). The gene discussed is CD3E; the disease is cranioectodermal dysplasia.