CD4 and cranioectodermal dysplasia: For CD4+ T cells, the genes upregulated after the seroconversion for CeD (Figures 4A, B) were significantly enriched for pathways related to immune-related functions (P adjusted value < 0.05) such as “TCR signaling” and “Generation of second messenger molecules” and mainly included genes such as CD3G, CD3E and CD3D (Figure 4A and Supplementary Table 4).