In ADP-Heat Shock Protein (ADP-HSP) immunized macaques, profilin can up-regulate the expression of apolipoprotein B mRNA-editing enzyme-catalytic polypeptide-like 3G (APOBEC3G), and increase the level of IgG against CD4+ T cells, which provides a new direction of therapy in HIV infection (346). The gene discussed is CD4; the disease is HIV infectious disease.