Relatedly, simultaneous knockdown of WASp and N-WASP in B cells results in more severe proliferation defects in B cells and reduced levels of IgG autoantibodies compared to specific knockdown of the WASp gene, suggesting that N-WASP expression in B cells is required for the development of autoimmunity, which signifies N-WASP as a new therapeutic target to control autoimmunity in WAS patients (299). Here, WASL is linked to Wiskott-Aldrich syndrome.