First, all IIM patients had decreased memory B cells, low RP105/CD180 surface B cell expression, and reduction of circulating CD3+CXCR3+ subsets, including Th1, Th1Th17, CXCR3+Th2, and CXCR3+Th17 cells. The gene discussed is CD180; the disease is acquired idiopathic inflammatory myopathy.