Figure 5B shows that Cluster A is comprised of a CD4+ naïve T cell subset with high levels of CCR7, CXCR4, and CD127 expression while Cluster B consists of a CD4+ effector memory cell subset positive for CX3CR1 and PD1. CITRUS also identified several populations of T cells that were decreased in IIM patients (Supplemental Figure S5). Here, CX3CR1 is linked to acquired idiopathic inflammatory myopathy.