As altered IL17 and IL10 levels were observed, which are crucial in Th17 and Treg differentiation and Th17 and Treg were reported to play indispensable roles in RA (42–44), the abundance of CD4+IL17+ and CD4+ CD25+FOXP3+ cells in mice inguinal lymph node was evaluated by flow cytometry. Here, FOXP3 is linked to rheumatoid arthritis.