Although the study of Gonder and colleagues showed that the conditional knockout of AHR in CD19+ B cells of the Eμ-TCL1 mouse model seems to have no impact on CLL progression or survival in vivo (42), we demonstrated that AHR silencing on CLL cells significantly increased apoptosis of CD19+ clones in vitro. This evidence concerns the gene AHR and B-cell chronic lymphocytic leukemia.