A phase III randomized, double-blind, active comparator- and placebo-controlled study have been showed that Secukinumab can improve the signs and symptoms of patients with active RA (149), while a phase II randomized study found that Ixekizumab improved the signs and symptoms of RA in patients who showed an inadequate response to TNF inhibitors (150). The gene discussed is TNF; the disease is rheumatoid arthritis.