Compared with patients without cryoglobulinemia, the patients with baseline cryoglobulinemia were more frequently female; had higher FIB-4 indexes, IgG and IgM levels; had higher cirrhosis rates; and had lower HCV RNA, TC, eGFR, C3 and C4 levels and platelet counts (Table 1). Here, C4A is linked to cryoglobulinemia.