Compared with patients without cryoglobulinemia, patients with cryoglobulinemia had higher cirrhosis rates and FIB-4 indexes and lower TC levels and platelet counts, indicating that mixed cryoglobulinemia was associated with cirrhosis and poor cholesterol synthesis (3, 10), while patients with cryoglobulinemia had higher levels of IgG and IgM and lower levels of C3, C4 and HCV RNA, reflecting the paramount phenotype of mixed cryoglobulinemia (3, 10, 26). This evidence concerns the gene C4A and cryoglobulinemia.