(1) Of 422 CHC patients, 227 (53.2%) had baseline cryoglobulinemia; these patients were more frequently female; had higher FIB-4, IgG and IgM levels and cirrhosis rates; and had lower HCV RNA, TC, eGFR, C3 and C4 levels and platelet counts than patients without cryoglobulinemia. The gene discussed is C4A; the disease is cryohydrocytosis.