CD40LG and cryoglobulinemia: Baseline IgM significantly predicted posttherapy cryoglobulinemia, and the associated areas under the curve (AUCs) were as follows: 12-week posttherapy cryoglobulinemia, 0.703 (cut-off value: >130 mg/dL, p<0.001, Figure 3A); 24-week posttherapy cryoglobulinemia, 0.691 (cut-off value: >105 mg/dL, p<0.001, Figure 3B); 48-week posttherapy cryoglobulinemia, 0.738 (cut-off value: >118 mg/dL, p<0.001, Figure 3C); and 4-year posttherapy cryoglobulinemia, 0.677 (cut-off value: >168 mg/dL, p=0.033, Figure 3D).