(1) Of 422 CHC patients, 227 (53.2%) had baseline cryoglobulinemia; these patients were more frequently female; had higher FIB-4, IgG and IgM levels and cirrhosis rates; and had lower HCV RNA, TC, eGFR, C3 and C4 levels and platelet counts than patients without cryoglobulinemia. Here, C3 is linked to cryoglobulinemia.