CDK5RAP2 and Primary microcephaly: Plays a critical role in cell cycle; loss of CDK5RAP2 function associated with reduced numbers of neural progenitor cells (NPCs); mutations in CDK5RAP2 are linked to primary microcephaly (42, 43); mutations in CDK5RAP2 were identified in case of vertically transmitted ZIKV infection with congenital syndrome (44).