RIGI and infection: The ZIKV/Gas6 complex activates AXL kinase activity which induces the transcription of TOLL-like receptor 3 (TLR3), DExD/H-Box helicase 58 (DDX58), and interferon induced with helicase C domain 1 (IFIH1) as well as several interferon-stimulated genes (ISGs), leading to suppression of the innate immune response and subsequent productive infection (Figure 2) (53, 54).