STING1 and STING-associated vasculopathy with onset in infancy: The palmitoylation of two membrane-proximal Cys residues (C88/91) of STING1 is crucial for STING1 activation, even for gain-of-function STING1 mutants in SAVI patients, which makes STING1 constitutively expressed on Golgi (49, 53).