O-GlcNAcylation of signal transducer and activator of the transcription (STAT)-3 resulted in defective STAT3 phosphorylation and IL-10 production, affecting STAT3–IL-10 signaling in macrophages, increasing disease severity in colitis models while inhibition of OGT-mediated O-GlcNAcylation protects against intestinal inflammation (143). This evidence concerns the gene STAT3 and colitis.