As an example, O-GlcNAc-pathway is able to modulate activity, production or pro-inflammatory environment of key component of innate immune response such as, Toll-like receptors, NF-κB pathway, circulating and endothelial cell adhering monocytes, macrophage infiltration and neutrophil lymphocyte ratio, players that are strongly association with the severity of hypertension. This evidence concerns the gene NFKB1 and hypertensive disorder.