We did not find any significant difference between patients initially hospitalized for moderate COVID-19 disease (n = 46) who later developed ARDS (n = 9) and those who did not (n = 37) [respectively, cell-free total DNA concentrations of 193 ng/ml (177–226) vs. 240 ng/ml (191–290), p = 0.14; MPO–DNA: 0.60 ST (0.40–2.2) vs. 1.2 ST (0.60–2.3), p = 0.58; and H3Cit OD measures: 0.21 (0.081–0.23) vs. 0.16 (0.10–0.31), p = 0.78] (Figures 2A–C). This evidence concerns the gene MPO and acute respiratory distress syndrome.