In the wild-type C57BL/6 mice lineage, infection was related to a significant increase (p <.05) in BUN levels, plasma GOT, plasma globulin, reticulocytes, and monocytes in blood and inflammatory cytokine levels (TNF-α, IL -10, IFN-γ, IL-12p40, and IL-17) and the number of cells and amastigote nests in cardiac tissues. The gene discussed is TNF; the disease is infection.