A significant decrease in the number of CD4+T cells was observed in the kidneys of MRL/lpr Fli1(+/-) mice compared with that of Fli1(+/+) nephritic mice; reducing Fli1 in lupus-prone mice would protect against lupus nephritis partially by regulating CXCR3 expression on T cells and reducing T-cell infiltration of kidneys (118). Here, CD4 is linked to systemic lupus erythematosus.