To prevent the occurrence of further skin reactions, about 57% of patients used hydrocolloid and/or silicone-based plasters, such as Eurofix® (Eurofarm, Belpasso, Italy) and Suprasorb® H (Lohmann & Rauscher GmbH & Co., Neuwied, Germany) to protect the skin before the application of insulin infusion sets or glycemic sensors. The gene discussed is INS; the disease is skin reaction.