IPA levels were decreased in liver fibrosis compared to those without fibrosis (p = 0.039 for all participants; p = 0.013 for 153 individuals without T2D); IPA levels negatively correlated with lobular inflammation (p = 0.039) and fibrosis (p = 0.039); IPA levels negatively correlated with fibrosis signaling genes, including ITGA3, ITGAV, LAMC3, and COL1A2 mRNA. The gene discussed is LAMC3; the disease is Hepatic fibrosis.