<h4>Background</h4>Multiple endocrine neoplasia type 1 (MEN1) is a hereditary endocrine syndrome caused by mutations in MEN1 tumor suppressor gene.<h4>Case presentation</h4>A 53-year-old Chinese female was admitted to Division of Endocrinology, Tongji Hospital, for hypercalcemic crisis. Here, MEN1 is linked to multiple endocrine neoplasia type 1.