(46) reported that at the current IFG cutoff (5.6–6.0 mmol/L) as proposed by the American Diabetes Association, children with obesity show similar acute insulin responsiveness to glucose, insulin sensitivity index, and disposition index to children with normal FBG, suggesting that IFG in children may not be clinically useful as in the adult obese populations. Here, INS is linked to obesity due to melanocortin 4 receptor deficiency.