In addition, other bioactive factors, such as leptin, adiponectin, tumor necrosis factor-α, interleukin-6, interleukin-8, and MCP-1, can also be released from perirenal fat, which is involved in the pathogenesis of CVD, metabolic disorders, and T2DM (25, 26). This evidence concerns the gene CXCL8 and Other metabolic disease.