PRDX6 and type 2 diabetes mellitus: Based on the relevance of Prdx6 in regulating both oxidative stress and mitochondrial function, strictly linked to T2DM development, we previously demonstrated that knockout mice for Prdx6 (Prdx6-/-) displayed a phenotype similar to an early stage of T2DM with a reduced GSIS and a higher level of muscle insulin resistance (13).