Second, while ten pivotal variables were enrolled for analysis, some information regarding important confounders including but not limited to Ki-67 index (41) and 21-Gene Recurrence Score (21-GRS) (42) as well as medical comorbidities and functional status, which tend to correlate with age and the prognosis of breast cancer, is now unavailable from the SEER database. The gene discussed is MKI67; the disease is breast carcinoma.