This speculation was based on several pieces of evidence: (1) OGDHL rs2293239 was predicted as highly deleterious by 9/13 algorithms; (2) this variant had a slightly higher frequency in the CONVERGE Chinese depressive women cohort (14) than in the non-psychotic controls (OR = 1.2602); (3) a literature search revealed that OGDHL is related to psychological diseases such as Alzheimer's disease (53), childhood disintegrative disorder (54), and cerebral atrophy (55); and (4) OGDHL is highly expressed in all regions of the human brain according to the Tissue Atlas database (56, 57). Here, OGDHL is linked to early-onset autosomal dominant Alzheimer disease.