TCF4 and malignant colon neoplasm: ITF2 is implicated as both a tumor suppressor and proto-oncogene in colon cancer (Davidsen et al., 2018); relevant to the current analysis, in human colon cancer cells and tissue, ITF2 is reported to prevent activation of the β-catenin-TCF4 complex and transcription of β-catenin gene targets (Shin et al., 2014).