C1QTNF9 and cardiac hypertrophy: In contrast, CTRP9-deficient mice show exaggerated cardiac hypertrophy, fibrosis, ERS-initiated apoptosis and oxidative stress compared with HFD-fed wild-type mice, indicating that CTRP9 neutralizes myocardial lipotoxicity and inhibits cardiac hypertrophy (Zuo et al., 2020b).