Additionally, it was reported that CTRP9 alleviated inflammation, apoptosis by activating AMPK, Nrf2 or protein kinase A-cAMP responsive element binding protein 1 pathway, thereby ameliorating MI or protecting against myocardial ischemia/reperfusion (MI/R) injury in rats (Kambara et al., 2015; Zhao D. et al., 2018; Liu et al., 2020). This evidence concerns the gene C1QTNF9 and myocardial ischemia.