In an intracerebral hemorrhage model induced by injecting bacterial collagenase into the striatum, Zhao et al. (2019) reveled that CTRP9 inhibitneuronal apoptosis via the AdipoR1/ phosphoinositide-3-Kinase, catalytic, delta polypeptide/Akt signaling pathway, suggesting that administration of CTRP9 may be a promising therapeutic strategy in intracerebral hemorrhage management. This evidence concerns the gene AKT1 and intracerebral hemorrhage.