Therefore, compared with that in the control group, the expression of CTRP9 mRNA in visceral adipose tissue of patients with obesity was significantly increased and was positively correlated with the steady-state model evaluation of insulin resistance (HOMA-IR) and waist circumference (Masoodian et al., 2020). The gene discussed is C1QTNF9; the disease is obesity due to melanocortin 4 receptor deficiency.