C3 and Alzheimer disease: RGN astrocytes can express inflammatory factors, such as IL-6 or IL-1β in CRND8Tg (Bouvier et al., 2016), iNOS in APP (V717I; Heneka et al., 2005), and C3 in 3xTg, Tg2576, and PS2APP mice (Fonseca et al., 2011; Wu et al., 2019) and TgF344-AD rats (Balu et al., 2019).