TARDBP and amyotrophic lateral sclerosis: Intraneuronal accumulation of misfolded, ubiquitinated/phosphorylated proteins, such as TDP-43, C9orf72 (C9), superoxide dismutase 1 (SOD1), and fused in sarcoma (FUS), is a major key factor in sporadic and familial ALS (sALS, fALS; for review, see Peters et al., 2015; Volk et al., 2018) but are not exclusive to ALS.