Intranuclear RNA foci have been observed not only in neurons but also in a small proportion of astrocytes in postmortem CNS tissue from C9-ALS patients (Lagier-Tourenne et al., 2013) as well as in iPSC-derived C9-mut astrocytes (Zhao et al., 2020). This evidence concerns the gene C9 and amyotrophic lateral sclerosis.