The specific expression of T34 human tau isoform selectively in astrocytes in a transgenic mouse model led to astrocytic morphological alterations resembling those found in corticobasal degeneration (CBD) or other primary tauopathies (see the section “Pieces of Evidence of Astrocyte Neurotoxicity in NDD Patient Samples”) called tufted astrocytes, astrocytic plaques, or threads (Forman et al., 2005). Here, MAPT is linked to Neurodevelopmental delay.