Recently, we found that CIH produced the upregulation of mRNA and protein levels of TRPC1, TRPC4, TRPC6, ORAI1, and STIM1 subunits in the rat lung tissue, which paralleled the vascular remodeling and pulmonary hypertension (Castillo-Galán et al., 2020), suggesting that STOC participate in the vascular alterations induced by CIH. This evidence concerns the gene ORAI1 and pulmonary arterial hypertension.