Solid experimental evidence indicates that Kir4.1/Kir5.1 channels are indispensable for the proper “plasma K+ sensing” of DCT cells and inactivation of Kir4.1 leads to impairment of Na+ reabsorption similar to the effect of hyperkalemia (Cuevas et al., 2017; Wang et al., 2018). This evidence concerns the gene KCNJ16 and Hyperkalemia.