It was reported that chronic CX3CL1 administration improves glucose tolerance in high-fat diet mice (Lee et al., 2013; Riopel et al., 2018), suggesting CX3CL1 is beneficial for DM treatment, but it is too early to say that CX3CL1 can be used to treat patients with DM before clarifying the cardiovascular outcome of CX3CL1. The gene discussed is CX3CL1; the disease is diabetes mellitus.