NFKB1 and acute respiratory distress syndrome: Isochlorogenic acid is also a natural compound with strong biological activity; isochlorogenic acid A could reduce the LPS-induced ALI by inhibiting the activation of the Nf-κB/NLRP3 signaling pathway, and it also has the effect of promoting apoptosis (Puangpraphant et al., 2011; Wang and Xiao, 2019; Liu et al., 2020).