In addition to direct actions in coronary arteries, GLP-1 RAs can prevent the formation and progression of coronary atherosclerosis through indirect mechanisms, such as maintaining glycemic control, losing weight, decreasing systolic blood pressure, obtaining beneficial effects from lipid levels, inhibiting platelet activation, reducing systemic inflammation and levels of circulating BNP (Sun et al., 2015a, 2015b; Song et al., 2015; Cameron-Vendrig et al., 2016; Barale et al., 2017; Mazidi et al., 2017; Sardu et al., 2018; Sternkopf et al., 2020; Trujillo et al., 2021). Here, GLP1R is linked to coronary atherosclerosis.