Beyond glycemic control, GLP-1 RAs have a beneficial role on the cardiovascular system through antagonizing the development of cardiovascular risk factors, such as obesity, and exerting protective effects on the heart and macro- and microcirculation (Clarke et al., 2018; Garg et al., 2019; Wang et al., 2020; Giugliano et al., 2021a). This evidence concerns the gene GLP1R and obesity due to melanocortin 4 receptor deficiency.