Previous researches showed that rebalancing NIM network was involved in the cognitive improving effects of LW-AFC on Alzheimer’s disease (AD) animal models, including the PrP-hAβPPswe/PS1ΔE9 (APP/PS1) mouse model and senescence-accelerated mouse prone 8 (SAMP8) strain (Wang et al., 2016a; Wang et al., 2017a). The gene discussed is APP; the disease is Alzheimer disease.