When further controlling for lipid profiles (TC, TG, LDL-C, and LDL-C) in Model 5, subjects in the highest tertile of serum RCAN2 levels also had a significantly increased risk of NAFLD (OR = 2.081, 95% CI = 1.084–3.995, p = 0.028). Here, RCAN2 is linked to metabolic dysfunction-associated steatotic liver disease.