Occurrence of hypoxia decreases the effectiveness of chemotherapy, radiotherapy, and PDT, which creates the demand for safe direct oxygen delivery approaches to the tumor tissues, using suitable carriers such as hemoglobin (Hb) and PFCs, a strategy to relieve hypoxic TME and improve therapeutic activity of PDT (Phung et al., 2020). This evidence concerns the gene GSTM1 and neoplasm.