The major findings of this study are as follows (Peerapornratana et al., 2019): ferroptosis is involved in SA-AKI; (Poston and Koyner, 2019); irisin post-treatment protects against SA-AKI by inhibiting ferroptosis; (Fani et al., 2018); the protective mechanism of irisin on SA-AKI depends on the SIRT1/Nrf2 pathway. Here, SIRT1 is linked to acute kidney injury.