HMOX1 and ischemia: NGR1 is one of the main active components in P. notoginseng and previous studies have shown that NGR1 could attenuate myocardial injury and reduce myocardial infarct size in an ischemia/reperfusion injury model (Tong et al., 2019), which may be through Nrf2-HO-1 or mTOR induced inflammation and apoptosis signaling pathway (Du et al., 2021; Liu et al., 2021).