We found that the expressions of p-AMPK were significantly decreased (p < 0.001) and the expressions of GPAT, SPTLC1 and SPTLC2 were all increased in the model group (p < 0.05, p < 0.001) compared with sham group, suggesting that production of toxic lipids were increased in HF mice heart. The gene discussed is SPTLC2; the disease is hydrops fetalis.