Here, in the myocardium of the hypertension-induced HFpEF, we also observed the increased expression of PGC-1a after CANA treatment, which was consistent with the increased expression of the mitochondrial membrane respiratory chain component protein subunit Ndufb4, COX2, Cox4i1, Cox5b, and Cox6a1. The gene discussed is COX6A1; the disease is Hypertension.