Here, in the myocardium of the hypertension-induced HFpEF, we also observed the increased expression of PGC-1a after CANA treatment, which was consistent with the increased expression of the mitochondrial membrane respiratory chain component protein subunit Ndufb4, COX2, Cox4i1, Cox5b, and Cox6a1. Here, COX4I1 is linked to Hypertension.