HMGCS2 and cardiomyopathy: However, study has shown that the Hmgcs2 overexpression is related to myocardial lipotoxicity caused by a high-fat diet in mice, and the inhibition of the upregulation of Hmgcs2 can reverse cardiomyopathy induced by lipotoxicity (Sikder et al., 2018; Li et al., 2021).