BECN1 and metastatic melanoma: Moreover, Beclin-1 and LC3 have been found to be overexpressed in advanced or metastatic melanoma as compared to early primary lesions, and have also been linked to cell proliferation markers like Ki67 expression (Miracco et al., 2010; Hara and Nakamura, 2012; Lazova et al., 2012; Maes et al., 2014).