CNR1 and Alzheimer disease: In contrast, an increase of CB1R immunostaining in the neocortex of APP/PS1 male mice at 3 months (Aso et al., 2012) or unchanged CB1R protein expression in the hippocampus and prefrontal cortex at 2 and 4 months of age in other AD animal models (Bedse et al., 2014b; Maccarrone et al., 2018) have been recently described.