In this sense, it has been previously demonstrated that CB2R activation reduces inflammatory processes, facilitates Aβ removal, modulates tau hyperphosphorylation and oxidative stress, and ameliorates cognitive abilities in AD mouse models (Ramírez et al., 2005; Van Der Stelt et al., 2006; Esposito et al., 2007; Fakhfouri et al., 2012; Aso et al., 2013; Wu et al., 2013; Aso et al., 2016; Li et al., 2019). The gene discussed is MAPT; the disease is Alzheimer disease.