CNR1 and Alzheimer disease: Accordingly, alterations in CB1R expression have been reported in both human AD brains (Manuel et al., 2014; Talarico et al., 2018; Berry et al., 2020; Medina-Vera et al., 2020) and AD mouse models (Kalifa et al., 2011; Aso et al., 2012; Bedse et al., 2014a).