SIRT3 and liver dysplastic nodule: At the molecular level, the importance of signaling pathways related to renal inflammation and fibrosis such as the loss of endothelial glucocorticoid receptor (Srivastava et al., 2021b), endothelial FGFR1 and SIRT3 signaling (Li J. et al., 2017; Srivastava et al., 2018), TGFβ/SMAD, Notch, WNT/β-Catenin, and Sonic-Hedgehog pathways (Marquez-Exposito et al., 2018; Zhao et al., 2018; Wang et al., 2022) have also demonstrated to play a relevant role in DN.