Notably, these mice also showed impaired neutrophil influx after intraperitoneal MSU injection, demonstrating that the NLRP3 inflammasome is an important link between the well-established causal stimulation of gout and the subsequent pathological features of acute gout attacks (Martinon et al., 2006; Amaral et al., 2012). This evidence concerns the gene NLRP3 and gout.