To determine whether Src and Lyn are involved in the role of SEP on filopodia formation and macrophage phagocytosis, RAW264.7 cells were administrated with pharmacological inhibitors targeting Src family (AZD0530) and ROCK1 (Y-27632) for 2 h prior to E. coli infection. The gene discussed is LYN; the disease is escherichia coli infection.