The lower expressions of PI3K/AKT inhibit the downstream NF-κB signal transduction, which could reduce the production of inflammatory factors and various chemokines in renal fiber formation and prevent the transformation of fibroblasts into myofibroblasts with stronger secretion and proliferation ability to improve kidney injury and reduce renal fibrosis and glomerular sclerosis, etc. (Liu X et al., 2018; He et al., 2019). Here, PIK3CA is linked to renal fibrosis.