In the core network c, we found 11 direct targets, VCAM1, RELA, CDK2, JUN, CDK1, HSP90AA1, NOS2, SOD1, CASP3, AHSA1, PTGER3, which had the greatest correlation with Astragalus polysaccharides in treating pulmonary fibrosis. This evidence concerns the gene VCAM1 and pulmonary fibrosis.