By analyzing the target interaction network VCAM1,RELA,CDK2,JUN,CDK1,HSP90AA1,NOS2, SOD1,CASP3,AHSA1, PTGER3 are at the core of the network, which can be regarded as the key targets of Astragalus polysaccharides in treating pulmonary fibrosis. Here, HSP90AA1 is linked to pulmonary fibrosis.