The results of KEGG pathway enrichment analysis are shown in Figure 2A, mainly including Pathways in cancer, Malaria, TNF signaling pathway, NF-kappa B signaling pathway, Rheumatoid arthritis, Non-alcoholic fatty liver disease (NAFLD), Leishmaniasis, Pertussis, Inflammatory bowel disease (IBD), PPAR signaling pathway, Tuberculosis, Chagas disease (American trypanosomiasis), Amoebiasis, Herpes simplex infection, Hepatitis B, Amyotrophic lateral sclerosis (ALS), Small cell lung cancer, NOD-like receptor signaling pathway, MAPK signaling pathway etc. The gene discussed is TNF; the disease is leishmaniasis.