In the core network c, we found 11 direct targets, VCAM1, RELA, CDK2, JUN, CDK1, HSP90AA1, NOS2, SOD1, CASP3, AHSA1, PTGER3, which had the greatest correlation with Astragalus polysaccharides in treating pulmonary fibrosis. The gene discussed is RELA; the disease is pulmonary fibrosis.