The expression level of TMEM16A channels is altered in cardiovascular diseases such as systemic hypertension (Wang et al., 2012; Wang et al., 2015), pulmonary hypertension (Forrest et al., 2012; Sun et al., 2012; Papp et al., 2019), and diabetic gastroparesis (Mazzone et al., 2011). The gene discussed is ANO1; the disease is pulmonary hypertension.