Indeed, recent data from our laboratory demonstrated that apocynin, a free radical scavenger and a Nox2 inhibitor, attenuated airway inflammation and muscle impairments by CS exposure (Chan et al., 2021), suggesting the effectiveness and feasibility of targeting oxidative stress by pharmacological means to treat lung and systemic manifestations of COPD. The gene discussed is CYBB; the disease is chronic obstructive pulmonary disease.