It is reported that JNK inhibition protected against the ALI animal models by ameliorating lung histopathologic changes and lung edema, reducing inflammatory cell infiltration, and inhibiting the secretion of pro-inflammatory cytokines TNF-α and interleukin (IL-6) (Shen et al., 2017; Jin and Jin, 2018). The gene discussed is MAPK8; the disease is acute respiratory distress syndrome.