STAT3 and pancreatic neoplasm: In other studies, NF-κB and signal transducer and activator of transcription 3 (Stat3) were found to be activated in pancreatic cancer, and bruceine D (4) could inhibit cell proliferation and induce cell apoptosis via attenuating the activation of the redox-sensitive p38-MAPK pathway (Lau et al., 2009) and suppressing NF-κB anti-apoptotic activity (Lau et al., 2010).