The main findings are as follows: 1) the expression of chemerin and CMKLR1 was upregulated in the lungs of MCT/hypoxia induced PH rats; 2) CMKLR1 expression was significantly increased in PASMCs under hypoxic conditions; 3) PASMC stimulation with exogenous chemerin promoted cell proliferation and migration via the ERK1/2 signaling pathway; and 4) the expression of chemerin protein was significantly increased in plasma of IPAH patients. The gene discussed is RARRES2; the disease is idiopathic pulmonary arterial hypertension.